Intended Use:
Inotech's Heparin Adsorbent is intended for the in vitro removal of heparin from the plasma of patients on heparin therapy or from plasma transported in heparin based anticoagulation tubes, prior to coagulation testing. Each tube will remove at least 2 Units of heparin per ml of plasma, returning APTT and TT values to baseline.
| Product No. | Quantity | |
| HA-1 | 10 tubes/pack | 10% discount on order of 10 or more packs |
Packaging:
Inotech's Heparin Adsorbent is supplied in 10x75mm polystyrene test tubes (10 per pack) sealed in a foil lined pouch.
Materials/Reagents:
Each tube contains 40mg of Heparin Adsorbent.
Shelf-Life
Tubes sealed in the foil lined pouch, maintained at room temperature (RT), have a shelf-life of 18 months beyond the date of manufacture. Once removed from the foil pouch, the exposed tubes have a shelf-life of 45 days when stored at RT in a high humidity sealed container (e.g. plastic box or zip-lock bag with a small aliquot of water or moistened paper towel added); or up to 35 days in a refrigerator, again in a sealed container. Water condensation on the inside walls of the tubes will not interfere with product performance.
Quality Control
Each lot is tested for the adsorption of heparin from human plasma by the manufacturer's laboratory and independently by a university hospital.
Performance Characteristics
Studies have shown that Inotech's Heparin Adsorbent will effectively remove at least 2 units of heparin per ml of plasma.
A comparison between untreated plasma samples and plasma samples with heparin added in vitro, which were then processed with Heparin Adsorbent, showed the APTT and TT values of the heparin containing plasma to return to the non-heparin plasma baseline values.
Assays for factors II, V, VII, VII, IX, X, XI, and XII were performed on 48 different plasma samples to which heparin was added in vitro and then processed with Heparin Adsorbent. Results showed no significant activity loss for the factors tested. Plasma samples obtained for the factor determinations were from normal subjects.
References
1. Penner, J.; Kelly, P.: American Dade: Anticoagulants: Heparin and Coumadin; p.55-76.
2. Rosenburg, R.D.: Actions and Interactions of Antithrombin and Heparin; N.Engl.J.Med. 292:146-151 (1975).
3. Hudson, P.: American Dade: The Activated Partial Thromboplastin Time Test: A Laboratory Procedure
for Factor Deficiency Screening and Heparin Monitoring (1983).
4. Thompson, A.R.; Counts, R.B.: Removal of Heparin and Protamine from Plasma; J. Lab. Clin. Med. 88:6 922-929 (1976).